abstract：:Stromal cells isolated from lymph nodes of adult T-cell leukemia/lymphoma (ATL) patients were cultured. Such lymph node stromal cells (LNSC) could be maintained for more than one year, whereas LNSC from other lymphoproliferative disorders ceased to proliferate within months. The rate of human T lymphotropic virus type...

journal_title：International journal of oncology

authors： Joh T,Yamada Y,Seto M,Nakamura S,Ohmoto Y,Kamihira S,Tomonaga M,Shiku H

更新日期：1996-10-01 00:00:00

abstract：:Cancer antigens RAK-p120, p42, and p25, which exhibit biological, immunological and molecular similarity to the proteins expressed by Human Immunodeficiency Virus 1 (HIV-1), were found in 47 of 47 tested cases of serous adenocarcinoma of the ovary, and 45 of 45 tested cases of squamous carcinoma of the cervix. Normal ...

journal_title：International journal of oncology

authors： Rakowiczszulczynska E,Roszak A,Mackiewicz A,Markowska J,McIntosh D,Karczewska A,Godlewski D,Snyder W,Leary D,Smith M

更新日期：1996-10-01 00:00:00

abstract：:We examined the clinical significance of E-cadherin and vimentin expression in 83 patients with breast dancer. E-cadherin expression was correlated with axillary metastases, histologic grade, recurrence and disease-free survival, but not with overall survival. On the other hand, vimentin expression was correlated with...

journal_title：International journal of oncology

authors： Yagasaki R,Noguchi M,Minami M,Earashi M

更新日期：1996-10-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:Gliomas are malignant brain tumors thought to arise through multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cyclin D1 gene encodes a proto-oncogenic cell cycle regulator implicated in the pathogenesis of several types of cancer, including gliomas. Northe...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-09-01 00:00:00

abstract：:The prognosis of patients carrying glottic squamous cell carcinomas (GSCCs) involving the anterior commissure is often unpredictable. In order to assess the possible prognostic role of new and reliable parameters, p53 and cyclin D1 protein expression was immunohistochemically analysed in pathological samples from 27 p...

journal_title：International journal of oncology

authors： Pignataro L,Capaccio P,Pruneri G,Carboni N,Fracchiolla N,Richelda R,Scaramellini G,Neri A,Buffa R

更新日期：1996-09-01 00:00:00

abstract：:An overview of the current mechanisms identified as associated with the expression of multidrug resistance is provided. The clinical relevance of multidrug resistance associated with the overexpression of the three major drug resistance-associated proteins namely, P-glycoprotein, MRP and/or LRP, is discussed. Alternat...

journal_title：International journal of oncology

authors： Hill B

更新日期：1996-08-01 00:00:00

abstract：:Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reacti...

journal_title：International journal of oncology

authors： Tait L,Dawson P,Wolman S,Galea K,Miller F

更新日期：1996-08-01 00:00:00

abstract：:The prognostic significance of Ki 67/MIB1 immunohistochemical assays (ICAs) was investigated in optimal technical conditions in 139 breast carcinomas. Automated ICAs (immunoperoxidase/Ventana device) was performed on frozen sections. Immunoprecipitates were quantified by computerized analysis (SAMBA) of digitized micr...

journal_title：International journal of oncology

authors： Charpin C,Garcia S,Bouvier C,Devictor B,Andra L,Lavaut M,Allasia C,Bonnier P

更新日期：1996-08-01 00:00:00

abstract：:We investigated Fas expression and Fas-mediated apoptosis on 25 surgically resected renal cell carcinoma (RCC) tissues and 8 RCC cell lines. Immunohistochemistry demonstrated that cancer cells in the 25 tissues expressed Fas (100%). Fas expression was confirmed in all cell lines at protein and mRNA levels, but the 7 c...

journal_title：International journal of oncology

authors： Inoue M,Yano H,Kojiro M

更新日期：1996-07-01 00:00:00

abstract：:Growth and differentiation of MCF-7 breast adenocarcinoma cells were studied in mixed cultures of MCF-7 cells and PA 16/23 myoepithelial cells and in isolated cultures of MCF-7 cells grown in the absence and presence of conditioned medium of PA 16/23 cells. In the cocultures, the MCF-7 cells grew in smaller aggregates...

journal_title：International journal of oncology

authors： Bani D,Magnelli L,Gallo O

更新日期：1996-07-01 00:00:00

abstract：:Specific RE protein species modulated by autocrine TGF alpha are unknown. HCT116 cells transfected with TGF alpha antisense expression vector were compared with control HCT116 NEO for mitogenesis and modulation of high MW (130, 120 kD) and low MW (116, 110, 105 kD) RE species. Nutrients alone (N) induced maximal mitog...

journal_title：International journal of oncology

authors： Dobre C,Ziober B,Humphrey L,Brattain M

更新日期：1996-06-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00

abstract：:We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and...

journal_title：International journal of oncology

authors： Maruiwa M,Yano H,Fukuda K,Ogasawara S,Hisaka T,Yamaguchi R,Kojiro M

更新日期：1996-06-01 00:00:00

abstract：:Thirty patients who underwent hepatectomy for the treatment of hepatocellular carcinoma (HCC) were examined for expression of HLA class I antigens on HCC cells by flow cytometry. The expression was found significantly lower in cases of stage IV compared with those of stage I or stage II (p<0.05), and in cases of intra...

journal_title：International journal of oncology

authors： Nishibe M,Une Y,Kobayashi M,Kuramitsu Y,Hosokawa M,Uchino J

更新日期：1996-06-01 00:00:00

abstract：:We compared the responses of c-Jun/AP-1 transcriptional complexes with those of NF-kappa B, an established hypoxia-inducible transcriptional complex, in hypoxic SiHa human squamous carcinoma cells. We observed that NF-kappa B was activated rapidly, while AP-1 activation was detectable only after prolonged hypoxia. How...

journal_title：International journal of oncology

authors： Laderoute K,Calaoagan J,Mendonca H,Ausserer W,Chen E,Giaccia A,Sutherland R

更新日期：1996-05-01 00:00:00

abstract：:A series of different human MDR (multidrug-resistant) cell lines including a HeLa-MDR1 transfectant which exhibit high overexpression of the MDR1/P-glycoprotein gene, but no enhanced expression of the MRP (multidrug resistance associated protein) gene, showed different ratios of relative resistances to the taxanes tax...

journal_title：International journal of oncology

authors： Ise W,Heuser M,Sanders K,Beck J,Gekeler V

更新日期：1996-05-01 00:00:00

abstract：:SK-N-SH human neuroblastoma cell line was employed to test whether direct introduction of the RII beta subunit of PKA could induce growth inhibition and reverse-transformation of cancer cells. We infected SK-N-SH cells with an RII beta expression construct and the clonal line with the highest expression level was sele...

journal_title：International journal of oncology

authors： Kim S,Lee G,Chochung Y,Park S,Hong S

更新日期：1996-04-01 00:00:00

abstract：:Spontaneous tumor regression is still one of the most puzzling events in human cancer. A cell culture model of malignant transformation designed to permit the study of this phenomenon in vitro was applied to examine reversion and re-expression of the transformed phenotype in two X-ray transformed mouse 10T1/2 cell clo...

journal_title：International journal of oncology

authors： Paquette B,Wagner R,Little J

更新日期：1996-04-01 00:00:00

abstract：:The enzyme poly(ADP-ribose)polymerase (PARP) has been implicated in several cellular processes by the demonstration of ADP-ribosylation of proteins which play a role in cellular repair of DNA damage, response to ionizing radiation and apoptosis. In addition, ADP-ribosylation has been shown to play a role in cell cycle...

journal_title：International journal of oncology

authors： Ramsamooj P,Prasad S,Dritschilo A,Notario V

更新日期：1996-04-01 00:00:00

abstract：:Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...

journal_title：International journal of oncology

authors： Hardell L,Fredrikson M,Axelson O

更新日期：1996-03-01 00:00:00

abstract：:A new continuous cell line from a human malignant carcinoid of the small intestine (KRJ-I) was established. The cells showed morphological and immunocytochemical features of the tumor of origin and expressed estrogen receptors. The cells are growing as a suspension, forming multicellular aggregates and spheroids. Elec...

journal_title：International journal of oncology

authors： Pfragner R,Wirnsberger G,Niederle B,Behmel A,Rinner I,Mandl A,Wawrina F,Luo J,Adamiker D,Hoger H,Ingolic E,Schauenstein K

更新日期：1996-03-01 00:00:00

abstract：:Gamma linolenic acid (GLA) is an anti-cancer agent recently reported to inhibit tumour cell-matrix attachment. This study examined the effects of GLA on the adhesion of two tumour cell lines, HT115 (human colon) and MDA MB 231 (human breast), to an extracellular matrix, Matrigel. The action of GLA on focal adhesion ki...

journal_title：International journal of oncology

authors： Jiang W,Hiscox S,Puntis M,Hallett M,Bryce R,Horrobin D,Mansel R

更新日期：1996-03-01 00:00:00

abstract：:The inhibitor of oxidative phosphorylation, 2,4-dinitrophenol (DNP), abrogates etoposide cytotoxicity in murine leukemia L1210 cells without affecting the quantity of drug-induced DNA lesions. Cell cycle arrest and events associated with cell death were followed in etoposide treated L1210 cells under conditions in whi...

journal_title：International journal of oncology

authors： Lock R,Thompson B,Stribinskiene L

更新日期：1996-02-01 00:00:00

abstract：:To investigate the relationships of the gross appearance to cancer depth and microinvasion in gallbladder cancer, thirty-three cancers were macroscopically subgrouped: papillary (n=8), nodular (n=6), papillo-invasive (n=1), nodulo-invasive (n=11), and invasive (n=7) type, respectively. Papillary type cancers were limi...

journal_title：International journal of oncology

authors： Namieno T,Takahashi M,Koito K,Sato N,Uchino J

更新日期：1996-02-01 00:00:00

abstract：:Cytokine production in squamous cell carcinoma (SCC) of the head and neck may directly influence the clinical behavior of this aggressive neoplasm since cytokines act as autocrine/paracrine growth factors, as well as immunomodulators. In the present study, the cytokine profiles of 16 SCCs of the head and neck and matc...

journal_title：International journal of oncology

authors： Sabourin C,Wang Q,Mallery S,Nicholson R,Gopalakrishnan R,Lang J,Schuller D,Stoner G

更新日期：1996-01-01 00:00:00

abstract：:We have carried out three rounds of screening tests using 239 synthetic tripeptides for the growth-inhibitory activity toward tumor cells and found that those having amino acid sequences of Pro-Thr-Trp or Glu-Arg-Pro effectively inhibit proliferation of transformed cells. These peptides could be the fundamental struct...

journal_title：International journal of oncology

authors： Hiwasa T,Soeda C,Takanohashi S,Kobayashi H,Suzuki A,Ueyama T,Ike Y

更新日期：1996-01-01 00:00:00

abstract：:m-Chloroperoxybenzoic acid (CPBA),which induces ornithine decarboxylase activity as much as 12-O-tetradecanoylphorbol-13-acetate (TPA), was tested for its ability to induce DNA synthesis, hydroperoxide (HPx) production, and tumor promotion in mouse epidermis in vivo. After an early inhibition, CPBA stimulates DNA synt...

journal_title：International journal of oncology

authors： Chen G,Perchellet E,Gao X,Johnson F,Davis A,Newell S,Hemingway R,Bottari V,Perchellet J

更新日期：1996-01-01 00:00:00

abstract：:The expression of mucinous ovarian cancer (OVC) antigen by hybrid cell lines derived by fusing a malignantly transformed Bloom syndrome (BS) cell line (BS-SHI-4M OVC-MU) and mouse L cells has been studied. Cell surfaces of 16 hybrids which grew 12-40 days post-fusion have been analysed by using a number of sera from m...

journal_title：International journal of oncology

authors： Shiraishi Y,Taguchi T,Seguchi H

更新日期：1995-12-01 00:00:00

abstract：:Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cel...

journal_title：International journal of oncology

authors： Zwergel T,Burk U,Herter S,Lindenmeir T,Wullich B,Unteregger G

更新日期：1995-12-01 00:00:00

abstract：:Tumor-bearing mice with two different locally growing malignant tumors (epithelial like, MCG 101; malignant melanoma, K1735-M2) were used to evaluate the putative role of prostaglandins for survival and local tumor growth in experimental cancer. Daily systemic injections of indomethacin (1 mu g/g bw) were used to bloc...

journal_title：International journal of oncology

authors： Lonnroth C,Svaninger G,Gelin J,Cahlin C,Iresjo B,Cvetkovska E,Edstrom S,Andersson M,Svanberg E,Lundholm K

更新日期：1995-12-01 00:00:00

abstract：:Seventy-one patients with metastatic colorectal carcinoma(CRC) were treated with varying doses of the mouse monoclonal antibody (MAb) 17-1A. One patient achieved a partial remission (PR) (1%) with a survival duration of 114+ months. Further 10 patients showed a minor response (MR) or stable disease > 3 months (SD) (14...

journal_title：International journal of oncology

authors： Ragnhammar P,Frodin J,Hjelm A,Fagerberg J,Wersall P,Lindemalm C,Nilsson B,Fox K,Magnusson I,Ewerth S,Thor K,Secher E,Mellstedt H

更新日期：1995-11-01 00:00:00

abstract：:In the present study, we analyzed the proliferation and cytotoxic activities of LAK cells and initial phase TILs by stimulation with IL-4. IL-4 obviously inhibited the DNA synthesis of LAK cells and initial phase TILs at the concentration of 250 pg/ml and 25 pg/ml, respectively. Furthermore, IL-4 (25 ng/ml for LAK cel...

journal_title：International journal of oncology

authors： Tsunoda T,Tanimura H,Yamaue H,Iwahashi M,Tani M,Tamai M,Noguchi K,Mizobata S,Arii K

更新日期：1995-11-01 00:00:00

abstract：:The Drosophila ras2 and rop gene pair are governed by a common promoter. Characterisation of the Drosophila ras2/rop bidirectional promoter has revealed that a single major protein complex (M), composed of two subunits (factors A and B) interacts with two central promoter domains (regions A and B). To define the trans...

journal_title：International journal of oncology

authors： Lightfoot K,Tai A,Segev O

更新日期：1995-11-01 00:00:00

abstract：:Inhibin and activin, members of transforming growth factor beta (TGF beta) superfamily, have been localized immunohistochemically in fetal bovine heart endothelial cells (FBHE), suggesting that these cells produce inhibin/activin proteins. In addition, the mRNAs coding for alpha-, and beta A-subunits of inhibin/activi...

journal_title：International journal of oncology

authors： Ying S,Zhang Z

更新日期：1995-10-01 00:00:00

abstract：:Human pancreatic ductal adenocarcinomas overexpress the epidermal growth factor (EGF) receptor. Betacellulin is a mitogenic polypeptide that binds and activates this receptor. To determine whether betacellulin has a role in human pancreatic cancer, we studied its expression in cultured human pancreatic cancer cell lin...

journal_title：International journal of oncology

authors： Yokoyama M,Funatomi H,Kobrin M,Ebert M,Friess H,Buchler M,Korc M

更新日期：1995-10-01 00:00:00

abstract：:Two new tumor-suppressor genes, the cyclin dependent kinase 4 inhibitor gene (p16/CDKN2) and the von Hippel-Lindau disease gene (VHL), have been cloned and mapped on chromosomes 9p and 3p respectively, where putative tumor-suppressor genes of the oral squamous-cell carcinoma (SCC) may be present. In order to elucidate...

journal_title：International journal of oncology

authors： Uzawa K,Suzuki H,Yokoe H,Tanzawa H,Sato K

更新日期：1995-10-01 00:00:00

abstract：:Seven ovarian and one cervical human cancer cell lines were examined far their sensitivity or resistance to tumor necrosis factor, to three topoisomerase II inhibitors and to cisplatin. Only one line exhibited the multidrug-resistance phenotype and another one an 'atypical'-MDR phenotype. The combination of TNF and to...

journal_title：International journal of oncology

authors： Aluigi M,Debernardis D,Cimoli G,Ottoboni C,Parodi S,Russo P

更新日期：1995-09-01 00:00:00

abstract：:Chronic administration of 17 beta-estradiol to male Syrian hamsters for at least six months induces estrogen-dependent kidney tumors, which express high levels of c-fos mRNA compared to surrounding renal or control tissues. We have investigated the cellular localization of c-Fos oncoprotein in these tissues and studie...

journal_title：International journal of oncology

authors： Bhat H,Hacker H,Thompson E,Liehr J

更新日期：1995-09-01 00:00:00

abstract：:Gene amplification is an important phenomenon in the pathogenetics of malignancy. A method is defined which allows the determination of gene amplification from any sample from which RNA can be obtained, and requires no a priori knowledge of the cytogenetic or genomic state of the tumor. This method allows the determin...

journal_title：International journal of oncology

authors： Liang B

更新日期：1995-09-01 00:00:00